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KMID : 0895820040140020055
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Journal of Oriental Rehabilitation Medicine
2004 Volume.14 No. 2 p.55 ~ p.73
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The Study for the Prohibitive Effect of SBY-Ⅲ on Obesity Formation
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Yang Jae-Hoon
Kim Sung-Su
Shin Hyun-Dae
Lee Jong-Soo
Chung Seok-Hee
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Abstract
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Objective: This experimental study was designed to investigate the effect of SBY-Ⅲ extract on the body weight, plasma, UCP mRNA in obese rats.
Methods: The body weight gain, weight of the internal organs(epididymis, liver, adipose tissue), insulin, triglyceride, total cholesterol, HDL-cholesterol, total lipid, free fatty acid, expression of UCP mRNA were measured in obese rats administered SBY-Ⅲ extract for 8 weeks. These were then compared with those of control groups administered physiological saline.
Results: 1. In the sample group, the body weight decrease occurred significantly than that of control group(p<0.001). 2. In the sample group, epididymal fat weight showed significantly decrease than that of control group(P<0.05). 3. In the sample group, fat accumulation in liver showed significantly decrease than that of control group(P<0.001). 4. In the sample group, triglyceride, total cholesterol, total lipid, free fatty acid showed significantly decrease than that of control group(P<0.05, P<0.01). 5. In the sample group, UCP1 mRNA in BAT significantly decrease than that of control group(P<0.05).
Conclusions: These results shows that SBY-Ⅲ has effects on the management of obesity.
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KEYWORD
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SBY-Ⅲ, Obesity, Lipid, UCP, High Fat Diet
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